Genetics of kidney stone disease

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Kidney stone disease

Urinary stone disease is a frequent challenge for the urologic practitioner. Stones are the only disease mentioned by name in the Hippocratic Oath and the removal of bladder stones was one of the earliest surgical procedures provided by the first surgeon-barbers. In the last century, as technology has continued to advance at a more rapid pace, our ability to treat nephrolithiasis has paralleled...

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Recent population studies have found symptomatic kidney stone formers to be at increased risk for chronic kidney disease (CKD). Although kidney stones are not commonly identified as the primary cause of ESRD, they still may be important contributing factors. Paradoxically, CKD can be protective against forming kidney stones because of the substantial reduction in urine calcium excretion. Among ...

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BACKGROUND Hypocitraturia, or low urinary citrate excretion is known as a risk for nephrolithiasis. Though urinary citrate excretion is basically determined by acid-base balance, metabolic acidosis is not always manifest in urinary stone patients with hypocitraturia. From our stone clinic data, we estimated the incidence of hypocitraturia and addressed its causes in the absence of obvious acid-...

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Do Kidney Stone Formers Have A Kidney Disease?

Nephrolithiasis is a highly prevalent disorder affecting approximately one in eleven people and is associated with multiple complications including hypertension, cardiovascular disease, and chronic kidney disease. Significant epidemiologic associations with chronic kidney disease and ESRD have been noted and are reviewed herein, but debate persists in the literature as to whether kidney stone f...

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ژورنال

عنوان ژورنال: Nature Reviews Urology

سال: 2020

ISSN: 1759-4812,1759-4820

DOI: 10.1038/s41585-020-0332-x